Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity-3

<p><b>Copyright information:</b></p><p>Taken from "Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity"</p><p>http://www.biomedcentral.com/1471-2202/8/55</p><p>BMC Neuroscience 2007;8():55-55.</p><p>Published online 26 Jul 2007</p><p>PMCID:PMC1959237.</p><p></p>n. The EPSP is potentiated to a near doubling of the initial response. Test pathway (black symbols) and control pathway (gray symbols) are plotted as functions of time, each point indicating the average in 1 min (n = 10 experiments). (B) LTP is partially blocked by Ro25-6981 (0.5 μM; n = 2)/Ifenprodil (3 μM; n = 4) (total n = 6). (C) LTP is fully prevented when NVP-AAM077 (0.4 μM) is present (n = 5). (D) Bar diagram summarizes the data in A-C with mean ± S.E.M. LTP is measured at 60 min after tetanization relative to the initial baseline. Arrows in A-C indicate the tetani. Black bars indicate the duration of drug application. Inserts illustrate EPSP-traces taken at the indicated time points (a, b). Calibrations: 0.5 mV, 20 ms