DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein-2

the given times to inhibit novel protein synthesis, then the cell extracts were prepared, followed by immunoblotting analysis of c-Myc. (B) Quantification of c-Myc destruction following CHX treatment based on densitometrical scanning of the immunohybridization signals of c-Myc protein shown in panel A. The data are the means with standard deviation from three independent experiments. (C) Silencing DNA-PKcs promoted ubiquitination of c-Myc. CoIP product (IP) of c-Myc was detected by immunoblotting (IB) with anti-ubquitin antibody (upper panel), while 1/2 the amount of c-Myc immunoprecipitates were subjected to immunoblotting analysis with c-Myc antibody as a control (lower panel).<p><b>Copyright information:</b></p><p>Taken from "DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein"</p><p>http://www.molecular-cancer.com/content/7/1/32</p><p>Molecular Cancer 2008;7():32-32.</p><p>Published online 22 Apr 2008</p><p>PMCID:PMC2383926.</p><p>