Correct timing of anchoring center initiation is required for correct folial shape

<p><b>Copyright information:</b></p><p>Taken from "Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers"</p><p>http://www.neuraldevelopment.com/content/2/1/26</p><p>Neural Development 2007;2():26-26.</p><p>Published online 3 Dec 2007</p><p>PMCID:PMC2246128.</p><p></p> Superimposition of midline vermis tracings at E17.5, P0, P3 and adult show that the delay in anchoring center formation of the secondary fissure and premature anchoring center formation of the prepyramidal fissure in mutants result in the a misshapen lobule VIII. Grey arrows demarcate prepyramidal fissure; black arrows demarcate secondary fissure