Histamine metabolism influences blood vessel branching in zebrafish mutants-6

Ent vascular plexus. (B) When treated with 900 μM of the histamine synthesis blocker, urocanic acid, the caudal vein of a wild-type sibling formed much fewer vascular branches and even developed a -like swollen lumen. Red arrows, caudal veins. (C) Quantitative results of the suppression of urocanic acid on blood vessel branching in wild-type zebrafish embryos. Two clutches of wild-type embryos (blue and red bars) were treated with the vehicle (0.0015 hydrochloric acid), or 300 or 900 μM of urocanic acid in egg water, from 26–36 hpf at 28.5°C. The percentage of embryos with less branched caudal vein was scored at the end of treatment (Y-axis, n = 40 unless otherwise specified).<p><b>Copyright information:</b></p><p>Taken from "Histamine metabolism influences blood vessel branching in zebrafish mutants"</p><p>http://www.biomedcentral.com/1471-213X/8/31</p><p>BMC Developmental Biology 2008;8():31-31.</p><p>Published online 25 Mar 2008</p><p>PMCID:PMC2291033.</p><p>