Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis-0

On of pons. A large number of Rip-positive promyelinating oligodendrocytes, which had a starburst morphology (), were observed in both the control () and (). , High-power photomicrographs of each promyelinating oligodendrocytes, respectively. The promyelinating oligodendrocyte () exhibited an oval cell body with multiple filopodia and a profuse network of processes, similar to those of wild-type (). , Reticular formation of pons. There were many Rip-positive myelinating oligodendrocytes ensheathing longitudinal axon bundles. , High-power photomicrographs of the myelinating oligodendrocyte in the control () or (). Each myelinating oligodendrocyte had the multiple linear processes arrays connected to the cell body by primary processes (), indicating that they had commenced axonal ensheathment. Scale bars: 100 μm (A, B); 20 μm (C, D); 100 μm (E, F); 20 μm (G, H).<p><b>Copyright information:</b></p><p>Taken from "Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis"</p><p>http://www.biomedcentral.com/1471-2202/9/35</p><p>BMC Neuroscience 2008;9():35-35.</p><p>Published online 5 Apr 2008</p><p>PMCID:PMC2323389.</p><p>