Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis-7

N and , respectively, showing the ED1-positive cells in the internal granule cell layer of the paraflocculus. indicates a capillary. , Choroid plexus in the lateral ventricles at P14. , Coronal sections through the aqueduct of the P14 brain. indicates the abnormal accumulation of ED1-positive cells underneath the ependymal layer and the formation of polyp-like protrusions into the aqueductal lumen. , Higher magnification of ED1-positive cells in the abnormal protrusion shown in . , Scanning confocal image of a transverse section of a blood vessel in the pons at P21, representing the ED1-positive cells () and vWF-positive endothelial cells (), with nuclear staining by TOPRO3 dye (). indicates the vascular lumen. , Confocal images of immunofluorescence labeling with ED1 () and Iba1 () across the vasculature in the P21 cerebellum. represent ED1-positive and Iba1-positive elongated cells found in the perivascular region. , Confocal images of immunostaining for ED1 () and Iba1 () through the section of the internal granular cell layer of the P21 cerebellum. indicate the ED1-positive and Iba1-positive ramified microglia. Panels and represent pairs of double-stained photomicrographs. Scale bars: 200 μm (A-D); 50 μm (E-H); 100 μm (I, J); 25 μm (K); 20 μm (L); 20 μm (M, N). ChP, choroid plexus; , cerebral aqueduct.<p><b>Copyright information:</b></p><p>Taken from "Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: Implications of macrophage/microglial activation in the pathogenesis"</p><p>http://www.biomedcentral.com/1471-2202/9/35</p><p>BMC Neuroscience 2008;9():35-35.</p><p>Published online 5 Apr 2008</p><p>PMCID:PMC2323389.</p><p>