-6 receptor subunits, gp80 and gp130, as well as p21 protein were determined by Western blot analysis as described in Material and Methods. β-actin level in the same blot was used as an internal loading control for protein amount.<p><b>Copyright information:</b></p><p>Taken from "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways"</p><p>http://www.jhoonline.org/content/1/1/6</p><p>Journal of Hematology and Oncology 2008;1():6-6.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2438442.</p><p></p
We have investigated the activity of ITF2357, a novel hydroxamate histone deacetylase inhibitor, on ...
Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmar...
Epigenetic drugs such as histone deacetylase inhibitors (HDACIs) possess anticancer properties due t...
or 72 hours. The cell number was recorded at each time point. Diamond (♦), control; Square (■), 0.1 ...
Diamond (♦), control; Square (■), 0.1 μM; Triangle (), 5 μM; Cross (x), 10 μM. (B). Percent inhibiti...
measured by flowcytometry as described in the Material and Methods. The shift-down of fluorescence f...
As described in Material and Methods. Methylation-specific PCR was performed using primers specific ...
Multiple myeloma is a plasma cell malignancy and develops in the bone marrow. The myeloma bone disea...
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the p...
International audienceEpigenetic regulation is a dynamic and reversible process that controls gene e...
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the p...
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the p...
Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeost...
<p>A) MM.1s cells were treated with ACY-241 for 18 hrs and lysates western blotted for Ac-α-Tubulin,...
The unfolded protein response is responsible for the detection of misfolded proteins and the coordin...
We have investigated the activity of ITF2357, a novel hydroxamate histone deacetylase inhibitor, on ...
Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmar...
Epigenetic drugs such as histone deacetylase inhibitors (HDACIs) possess anticancer properties due t...
or 72 hours. The cell number was recorded at each time point. Diamond (♦), control; Square (■), 0.1 ...
Diamond (♦), control; Square (■), 0.1 μM; Triangle (), 5 μM; Cross (x), 10 μM. (B). Percent inhibiti...
measured by flowcytometry as described in the Material and Methods. The shift-down of fluorescence f...
As described in Material and Methods. Methylation-specific PCR was performed using primers specific ...
Multiple myeloma is a plasma cell malignancy and develops in the bone marrow. The myeloma bone disea...
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the p...
International audienceEpigenetic regulation is a dynamic and reversible process that controls gene e...
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the p...
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the p...
Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeost...
<p>A) MM.1s cells were treated with ACY-241 for 18 hrs and lysates western blotted for Ac-α-Tubulin,...
The unfolded protein response is responsible for the detection of misfolded proteins and the coordin...
We have investigated the activity of ITF2357, a novel hydroxamate histone deacetylase inhibitor, on ...
Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmar...
Epigenetic drugs such as histone deacetylase inhibitors (HDACIs) possess anticancer properties due t...