Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways-1

As described in Material and Methods. Methylation-specific PCR was performed using primers specific for methylated and unmethylated DNA forms of p16, respectively. The PCR product was visualized after agarose gel electrophoresis. Decitabine (5-aza) was used as a positive control for DNA hypomethylation. M, methylated p16 fragment; U, unmethylated p16 fragment. The 150 bp marker position was indicated.<p><b>Copyright information:</b></p><p>Taken from "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways"</p><p>http://www.jhoonline.org/content/1/1/6</p><p>Journal of Hematology and Oncology 2008;1():6-6.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2438442.</p><p>