The influence of nicotine on granulocytic differentiation – Inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release-2

S (V) some of which contain variably dense cores ; Five-day, DMSO-differentiated HL-60 cells without nicotine treatment (, ×2650); or exposed to 10M nicotine (, ×4300); or 10M nicotine (, ×2650) contain a markedly indented and segmented nucleus with pyknotic nuclear chromatin . The nucleolus has disappeared. Small uniformly dense granules as well as some large vacuoles with variably dense cores () were found in the DMSO-differentiated cells. : mitochondria. No qualitative changes to neutrophil ultrastructure could be ascribed to nicotine exposure during HL-60 differentiation. The bars represent 1 μm.<p><b>Copyright information:</b></p><p>Taken from "The influence of nicotine on granulocytic differentiation – Inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release"</p><p>http://www.biomedcentral.com/1471-2121/9/19</p><p>BMC Cell Biology 2008;9():19-19.</p><p>Published online 15 Apr 2008</p><p>PMCID:PMC2375863.</p><p>