The effects of nicotine on intact human granulocytes were examined, using 5-doxylstearic acid as a spin probe. At micromolar concentrations, (-)-nitocine produces a membrane perturbation in granulocytes not observable with oriented lipid bilayers. The effect, which is stereoselective for the (-)-isomer, occurs at concentrations of nicotine that bind to noncholinergic nicotine receptors on granulocytes and which are present in the blood after smoking. At comparable concentrations, (-)-nicotine modulates granulocyte chemotaxis towards a chemotactic peptide in a stereospecific and dose-dependent manner. Cotinine, the major metabolite of nicotine, does not bind to the receptor, does not produce the membrane perturbation observed with nicotine, ...
© 2016 Elsevier GmbH.Participation of nicotinic acetylcholine receptors (nAChRs) in functioning of p...
Background and aims: The effects of the mesenchymal stem cells (MSCs) on the neutrophil functions ha...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...
The effects of nicotine on intact human granulocytes were examined, using 5-doxylstearic acid as a s...
The noncholinergic nicotine receptor on leukocytes identified earlier [Davies et al., Molec. Cell. B...
S (V) some of which contain variably dense cores ; Five-day, DMSO-differentiated HL-60 cells without...
Reated and control HL-60 cells is also shown (top). Fourier self-deconvoluted (FSD) mean infrared sp...
μg) of five day, DMSO-induced HL-60 cells without nicotine, or with 10M nicotine, or with 10M nicoti...
μg) of five day, DMSO-induced HL-60 cells without nicotine, or with 10M nicotine, or with 10M nicoti...
Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels expressed in the mammalian...
We examined the direct effects of nicotine on a variety of neutrophil functions at concentrations ac...
NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same time contribute to...
BackgroundOver 1.1 billion people smoke worldwide. The alkaloid nicotine is a prominent and addictiv...
HL-60 cells stimulated with LPS (1.0 μg ml) plus nicotine (10M, Lane 2); compared to LPS alone (Lane...
In inflammatory pulmonary diseases, cigarette smoking is a major risk factor influencing the phenoty...
© 2016 Elsevier GmbH.Participation of nicotinic acetylcholine receptors (nAChRs) in functioning of p...
Background and aims: The effects of the mesenchymal stem cells (MSCs) on the neutrophil functions ha...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...
The effects of nicotine on intact human granulocytes were examined, using 5-doxylstearic acid as a s...
The noncholinergic nicotine receptor on leukocytes identified earlier [Davies et al., Molec. Cell. B...
S (V) some of which contain variably dense cores ; Five-day, DMSO-differentiated HL-60 cells without...
Reated and control HL-60 cells is also shown (top). Fourier self-deconvoluted (FSD) mean infrared sp...
μg) of five day, DMSO-induced HL-60 cells without nicotine, or with 10M nicotine, or with 10M nicoti...
μg) of five day, DMSO-induced HL-60 cells without nicotine, or with 10M nicotine, or with 10M nicoti...
Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels expressed in the mammalian...
We examined the direct effects of nicotine on a variety of neutrophil functions at concentrations ac...
NETs serve to ensnare and kill microbial pathogens. However, NETs can at the same time contribute to...
BackgroundOver 1.1 billion people smoke worldwide. The alkaloid nicotine is a prominent and addictiv...
HL-60 cells stimulated with LPS (1.0 μg ml) plus nicotine (10M, Lane 2); compared to LPS alone (Lane...
In inflammatory pulmonary diseases, cigarette smoking is a major risk factor influencing the phenoty...
© 2016 Elsevier GmbH.Participation of nicotinic acetylcholine receptors (nAChRs) in functioning of p...
Background and aims: The effects of the mesenchymal stem cells (MSCs) on the neutrophil functions ha...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...