High resolution melting analysis for rapid and sensitive and mutation detection in formalin fixed paraffin embedded biopsies-3

D TX64 in brown) and a positive mutation control (RPMI8226 in red) were compared to a wild-type sample. The wild-type control sample is shown as a horizontal line in blue. Four patients and the positive control samples had different melting profiles compared to the wild-type. Sequencing of the patients revealed four different amino acid changes at codon 12; p.G12D in TX23, p.G12F in TX41, p.G12V in TX55 and p.G12C in TX64.<p><b>Copyright information:</b></p><p>Taken from "High resolution melting analysis for rapid and sensitive and mutation detection in formalin fixed paraffin embedded biopsies"</p><p>http://www.biomedcentral.com/1471-2407/8/142</p><p>BMC Cancer 2008;8():142-142.</p><p>Published online 21 May 2008</p><p>PMCID:PMC2408599.</p><p>