Um (ENSMODP00000004651), fugu (NEWSINFRUP00000161615), tetraodon (GSTENP00027811001). b) KCNQ1: GenBank accession numbers/Ensembl identifiers for KCNQ1 protein sequences used: human (), mouse (), rat (), chicken (ENSGALP00000010441), fugu (NEWSINFRUP00000143259), zebrafish (ENSDARP00000077951). See methods for details.<p><b>Copyright information:</b></p><p>Taken from "Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations"</p><p>http://www.biomedcentral.com/1471-2148/8/188</p><p>BMC Evolutionary Biology 2008;8():188-188.</p><p>Published online 30 Jun 2008</p><p>PMCID:PMC2483723.</p><p></p
Long QT Syndrome (LQTS) is a cardiac disorder that results in lethal arrhythmia in individuals. KCNH...
current (IKr) is important for repolarization of the heart, and mutations in the genes coding for th...
K IR2.1 potassium channels, producing inward rectifier potassium current (I K1), are important for f...
12 nsSNPs at 12 sites. Blue region = voltage sensing domain (S1–S4), pink region = pore forming doma...
12 nsSNPs at 12 sites. Blue region = voltage sensing domain (S1–S4), pink region = pore forming doma...
a given amino acid was divided by the total number of residue sites in the combination of the two pr...
(see methods). Because of a low number of expected mutations in the more variable positions, the Xst...
Ions based on an evolutionary distribution within each region (gray). Disease mutations are unevenly...
Ities. A significant correlation is observed for both HERG (p < 0.0001) and KCNQ1 (p < 0.0001). c) P...
Background. Mutations in HERG and KCNQ1 potassium channels have been associated wit...
Hyperpolarization-activated cyclic nucleotide gated (HCN) channels are structurally similar to volta...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated ...
In this article, the authors use the zebrafish genome and potassium channels to study cardiac anomal...
Genome sequencing of individuals with intellectual disability, epilepsy disorders and other neurolog...
Analysis of the human KCNH2(HERG) gene: identification and characterization of a novel mutation Y667...
Long QT Syndrome (LQTS) is a cardiac disorder that results in lethal arrhythmia in individuals. KCNH...
current (IKr) is important for repolarization of the heart, and mutations in the genes coding for th...
K IR2.1 potassium channels, producing inward rectifier potassium current (I K1), are important for f...
12 nsSNPs at 12 sites. Blue region = voltage sensing domain (S1–S4), pink region = pore forming doma...
12 nsSNPs at 12 sites. Blue region = voltage sensing domain (S1–S4), pink region = pore forming doma...
a given amino acid was divided by the total number of residue sites in the combination of the two pr...
(see methods). Because of a low number of expected mutations in the more variable positions, the Xst...
Ions based on an evolutionary distribution within each region (gray). Disease mutations are unevenly...
Ities. A significant correlation is observed for both HERG (p < 0.0001) and KCNQ1 (p < 0.0001). c) P...
Background. Mutations in HERG and KCNQ1 potassium channels have been associated wit...
Hyperpolarization-activated cyclic nucleotide gated (HCN) channels are structurally similar to volta...
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated ...
In this article, the authors use the zebrafish genome and potassium channels to study cardiac anomal...
Genome sequencing of individuals with intellectual disability, epilepsy disorders and other neurolog...
Analysis of the human KCNH2(HERG) gene: identification and characterization of a novel mutation Y667...
Long QT Syndrome (LQTS) is a cardiac disorder that results in lethal arrhythmia in individuals. KCNH...
current (IKr) is important for repolarization of the heart, and mutations in the genes coding for th...
K IR2.1 potassium channels, producing inward rectifier potassium current (I K1), are important for f...