Studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol-1

Tion in colony forming is observed after incubation with genistein. Colony formation was reduced to 50% of the controls in LNCaP afer incubation with genistein 0.01 μM (p = 0.004). Higher genistein concentrations (0.1 μM and 10 μM) did not further suppress clonogenic survival. In PC-3 incubation with genistein 0.1 μM decreased colony formation to 75% of the controls (p = 0.027), higher concentrations reduced clonogenic survival further (10 μM: p < 0.001; 25 μM: p < 0.001).<p><b>Copyright information:</b></p><p>Taken from "studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol"</p><p>http://www.ro-journal.com/content/3/1/19</p><p>Radiation Oncology (London, England) 2008;3():19-19.</p><p>Published online 14 Jul 2008</p><p>PMCID:PMC2490684.</p><p>