Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G/M cell cycle arrest-0

<p><b>Copyright information:</b></p><p>Taken from "Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G/M cell cycle arrest"</p><p>BMC Cancer 2006;6():107-107.</p><p>Published online 26 Apr 2006</p><p>PMCID:PMC1464148.</p><p>Copyright © 2006 Raffoul et al; licensee BioMed Central Ltd.</p>on, cells were plated in a clonogenic assay. Cells from the PC-3 (prostate cancer), BR-231 (breast cancer), and KCI-18 and RC-2 (renal cell carcinoma) cell lines were treated with 15 μmol/L genistein for 24 hr then irradiated with 3 Gy photons and plated in a clonogenic assay. Colonies were stained with crystal violet and counted after 11–13 days incubation. The mean survival fraction ± S.E.M. of triplicate wells was normalized to control cells based on plating efficiency. (*): value statistically significant from control at < 0.05. Combined treatment was significantly greater (< 0.05) than genistein or radiation alone