<p><b>A:</b> Bar plot with SEM for all the expressed genes; significant differences are indicated with asterisks (<i>p</i><0.05 (*), <i>p</i><0.01 (**), <i>p</i><0.001 (***). <b>B:</b> Principal component analysis. The identification of 2 astrocytic subpopulations is along the first principal component, which accounts for most of the variation in the measured data. <b>C:</b> Clustering of astrocytes using Kohonen SOMs. The expression levels of all genes were mean-centered. Each dot represents one cell. <b>D:</b> Dendrogram based on all astrocytic genes. The y-axis shows the distance between groups.</p
<p>(A) Similarities between samples based on Principal Component Analysis. Expression of 82 genes li...
<p>(A) Two-dimensional PCA map of cell types, comparing PC1 and PC3. (B) Three-dimensional map compa...
Astrocytes perform control and regulatory functions in the central nervous system; heterogeneity amo...
<p><b>A:</b> Bar plot with SEM for all the expressed genes; significant differences are indicated wi...
Single-cell gene expression levels show substantial variations among cells in seemingly homogenous p...
Heatmap of expression values for top 6 most differential expressed genes (by effect size) for α-, β-...
<p>(a) Hierarchical clustering dendrogram of the 12 datasets (distance metric: “1-P”, linkage method...
<p>A) The array data were normalized and a hierarchical clustering was run. On top of the heatmap, t...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Program in Neurosc...
Scatterplot of principal component (PC) 9 against PC10 reveals two clouds representing core (black s...
<p>Pair wise comparison of control primary human astrocytes (No HIV infection) and clade B infected ...
<p>Astrocytes were isolated using an ACSA-2 antibody conjugated to magnetic microbeads. A, B, C) Qua...
<p><b>A)</b> We minimized experimental variation due to lab effects by performing uniform pre-proces...
Left panel: Plot of cell type marker genes detected as altered in AD compared to control samples bas...
<p>Subgroups of cells were identified based on the PCA of single-cell PCR gene expression analysis d...
<p>(A) Similarities between samples based on Principal Component Analysis. Expression of 82 genes li...
<p>(A) Two-dimensional PCA map of cell types, comparing PC1 and PC3. (B) Three-dimensional map compa...
Astrocytes perform control and regulatory functions in the central nervous system; heterogeneity amo...
<p><b>A:</b> Bar plot with SEM for all the expressed genes; significant differences are indicated wi...
Single-cell gene expression levels show substantial variations among cells in seemingly homogenous p...
Heatmap of expression values for top 6 most differential expressed genes (by effect size) for α-, β-...
<p>(a) Hierarchical clustering dendrogram of the 12 datasets (distance metric: “1-P”, linkage method...
<p>A) The array data were normalized and a hierarchical clustering was run. On top of the heatmap, t...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Program in Neurosc...
Scatterplot of principal component (PC) 9 against PC10 reveals two clouds representing core (black s...
<p>Pair wise comparison of control primary human astrocytes (No HIV infection) and clade B infected ...
<p>Astrocytes were isolated using an ACSA-2 antibody conjugated to magnetic microbeads. A, B, C) Qua...
<p><b>A)</b> We minimized experimental variation due to lab effects by performing uniform pre-proces...
Left panel: Plot of cell type marker genes detected as altered in AD compared to control samples bas...
<p>Subgroups of cells were identified based on the PCA of single-cell PCR gene expression analysis d...
<p>(A) Similarities between samples based on Principal Component Analysis. Expression of 82 genes li...
<p>(A) Two-dimensional PCA map of cell types, comparing PC1 and PC3. (B) Three-dimensional map compa...
Astrocytes perform control and regulatory functions in the central nervous system; heterogeneity amo...