<p>(A) Sequence alignment between miR-520b and the 3′UTR of human MEKK2 and cyclin D1 mRNA. Solid line, seed match region; dashed line, seed-mutated region. (B) The effect of miR-520b on the activity of firefly luciferase reporter containing either wild type (WT) or mutant type (Mut) 3′UTR was tested by luciferase reporter gene assays. (C) The effect of miR-520b or Inh-520b on the endogenous expression levels of MEKK2 and cyclin D1 was examined in HepG2 and H7402 cells by western blot analyses. β-actin was used as an internal control. The intensity for each band was quantified densitometrically.</p
<p>(A) The miR-132 binding site predicted in the 3′UTR of ZEB2 mRNA. (B) Mutant was generated at the...
<p>(A) Quantitative real-time PCR (QRT-PCR) analysis of miR-485-3p (left) and miR-194 (right) expres...
<p>(a, b) mir-424 inhibitor induces the protein expression of MEK1 and cyclin E1 but not mRNA expres...
<p>(A) The expression levels of MEKK2 and cyclin D1 were examined by western blot analyses in HepG2 ...
<p>(a) miR-545 inhibited the activity of luciferase containing the 3′UTR of the cyclin D1 or CDK4 ge...
<div><p>Growing evidence indicates that the deregulation of microRNAs (miRNAs) contributes to the tu...
<p>(A) The effect of miR-520b or sicyclinD1-1 on phosphorylation levels Rb (p-Rb) was examined in He...
<p>(A), Sequence alignments of miR-195 and its target sites in 3′-UTRs of Cyclin D1 or Bcl-2. (B), T...
<p>(A) The curve of tumor growth is shown. (B) Photograph of excised tumors 4 weeks after implantati...
<p>(<b>A</b>) Scheme for the identification of candidate genes combining microarray assays and a tar...
<p>′<b>-UTRs. A</b>, Predicted miR-195 target sequence in the 3′-UTR of cyclin D1 and cyclin E1 (cyc...
<p>(A) Total RNA from normal B-cells, DLBCL, BL, and HeLa cell lines were used to measure miR-520c-3...
<p>(A) Cumulative distribution functions (cdfs) of log<sub>2</sub> fold change of mRNA expression be...
<p>(A) Identification of miR-1 regulatory element in the 3′UTR of mouse Cyclin D1. (B) Evaluation of...
<p>(A) Specific locations of the binding sites were marked with red color and MITF, BCL2 and cyclin ...
<p>(A) The miR-132 binding site predicted in the 3′UTR of ZEB2 mRNA. (B) Mutant was generated at the...
<p>(A) Quantitative real-time PCR (QRT-PCR) analysis of miR-485-3p (left) and miR-194 (right) expres...
<p>(a, b) mir-424 inhibitor induces the protein expression of MEK1 and cyclin E1 but not mRNA expres...
<p>(A) The expression levels of MEKK2 and cyclin D1 were examined by western blot analyses in HepG2 ...
<p>(a) miR-545 inhibited the activity of luciferase containing the 3′UTR of the cyclin D1 or CDK4 ge...
<div><p>Growing evidence indicates that the deregulation of microRNAs (miRNAs) contributes to the tu...
<p>(A) The effect of miR-520b or sicyclinD1-1 on phosphorylation levels Rb (p-Rb) was examined in He...
<p>(A), Sequence alignments of miR-195 and its target sites in 3′-UTRs of Cyclin D1 or Bcl-2. (B), T...
<p>(A) The curve of tumor growth is shown. (B) Photograph of excised tumors 4 weeks after implantati...
<p>(<b>A</b>) Scheme for the identification of candidate genes combining microarray assays and a tar...
<p>′<b>-UTRs. A</b>, Predicted miR-195 target sequence in the 3′-UTR of cyclin D1 and cyclin E1 (cyc...
<p>(A) Total RNA from normal B-cells, DLBCL, BL, and HeLa cell lines were used to measure miR-520c-3...
<p>(A) Cumulative distribution functions (cdfs) of log<sub>2</sub> fold change of mRNA expression be...
<p>(A) Identification of miR-1 regulatory element in the 3′UTR of mouse Cyclin D1. (B) Evaluation of...
<p>(A) Specific locations of the binding sites were marked with red color and MITF, BCL2 and cyclin ...
<p>(A) The miR-132 binding site predicted in the 3′UTR of ZEB2 mRNA. (B) Mutant was generated at the...
<p>(A) Quantitative real-time PCR (QRT-PCR) analysis of miR-485-3p (left) and miR-194 (right) expres...
<p>(a, b) mir-424 inhibitor induces the protein expression of MEK1 and cyclin E1 but not mRNA expres...