a<p>The steady state(s) for the three models by scanning a)k<sub>1</sub> (SK autophosphorylation reaction rate constant) and b)k<sub>2</sub> (SKP autodephosphorylation reaction rate constant) between 10<sup>−6</sup> and 10 at different values of the parameters named in the table (see text for details).</p
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper underst...
<p>Each bar corresponds to a rate constant in the model and indicates a range of values for that rat...
<p>Model A represents a prototypical TCS. Model B represents a TCS with a SK-binding third component...
(A) A schematic of the phosphorylation module. Autophosphorylation and auto-dephosphorylation of the...
a<p>A|B stands for Model A controlled for Model B. A|C stands for Model A controlled for Model C.</p...
<p>The x- and y-axis show the signal (<i>k<sub>5</sub></i>) level and the corresponding steady state...
<p>Each plot shows the steady state levels of the phosphorylated RR in the y axis at different value...
<p>The percentage of parameter sets generating a bistable multisite phosphorylation system with or w...
<p>(a) Absolutely bistable models (<i>Bistability</i>>9.5); (b) Bistable models (<i>Bistability</i>>...
<p>The dose-response curves of the Casp9-mutant model (F), those of the wild-type model (G), and tho...
a<p>Some bidimensional sections of the multidimensional parameter space of bistability are shown in ...
<p>Examples of some of the parameters that had a greater effect when fine-tuned. Protein X and Y lev...
<p>Indexes of variables are A (as in k<sub>A</sub>, V<sub>A</sub>) for control (+DMSO) and B (as in ...
<p>(A) Self-activating gene with cooperativity. (B) Phosphorylation-dephosphorylation cycle. (C) Sch...
<p>Black and blue curves show stable steady state activity levels and ECM concentrations, depending ...
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper underst...
<p>Each bar corresponds to a rate constant in the model and indicates a range of values for that rat...
<p>Model A represents a prototypical TCS. Model B represents a TCS with a SK-binding third component...
(A) A schematic of the phosphorylation module. Autophosphorylation and auto-dephosphorylation of the...
a<p>A|B stands for Model A controlled for Model B. A|C stands for Model A controlled for Model C.</p...
<p>The x- and y-axis show the signal (<i>k<sub>5</sub></i>) level and the corresponding steady state...
<p>Each plot shows the steady state levels of the phosphorylated RR in the y axis at different value...
<p>The percentage of parameter sets generating a bistable multisite phosphorylation system with or w...
<p>(a) Absolutely bistable models (<i>Bistability</i>>9.5); (b) Bistable models (<i>Bistability</i>>...
<p>The dose-response curves of the Casp9-mutant model (F), those of the wild-type model (G), and tho...
a<p>Some bidimensional sections of the multidimensional parameter space of bistability are shown in ...
<p>Examples of some of the parameters that had a greater effect when fine-tuned. Protein X and Y lev...
<p>Indexes of variables are A (as in k<sub>A</sub>, V<sub>A</sub>) for control (+DMSO) and B (as in ...
<p>(A) Self-activating gene with cooperativity. (B) Phosphorylation-dephosphorylation cycle. (C) Sch...
<p>Black and blue curves show stable steady state activity levels and ECM concentrations, depending ...
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper underst...
<p>Each bar corresponds to a rate constant in the model and indicates a range of values for that rat...
<p>Model A represents a prototypical TCS. Model B represents a TCS with a SK-binding third component...