Percentage of parameter space where bistable responses are possible^a.

a<p>Some bidimensional sections of the multidimensional parameter space of bistability are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031095#pone.0031095.s002" target="_blank">Figure S2</a>. The results show that in TCS with a bifunctional SK, both a TC_SK and a TC_RR cause a decrease in the size of the parametric region of bistability, with one exception: Model C has a larger parametric region of bistability when the signaling target is SK autophosphorylation (k₁). However, in systems with a monofunctional SK, a TCSK causes an increase and a TCRR causes a decrease in the size of the parametric region of bistability if the environment modulates the SK dephosphorylation (k₂). A|B stands for Model A controlled for Model B. A|C stands for Model A controlled for Model C.