Representative longitudinal MRI of wobbler mouse brains 1 day after ICV administration of PBS (A), hAFCs labeled with SPIOn (B) and iron-free hAFCs (C).

<p>Representative longitudinal MRI of the same mouse brain 28 days after ICV administration of PBS (<b>D</b>), hAFCs labeled with SPIOn (<b>E</b>) and iron-free hAFCs (<b>F</b>). Arrows indicate the different compartments of brain ventricles: L.V.: lateral ventricle; CB: cerebellum; S.C.: spinal cord. Representative longitudinal MRI of wobbler mouse brains before (<b>G</b>), 1 (<b>H</b>), 24 (<b>I</b>) and 48 hours (<b>J</b>) after SPIOn administration. For each panel, the sagittal slice is representative of the region comprising lateral ventricles (L.V.), cerebellum (CB) and fourth ventricle at the spinal cord level (S.C.), as indicated by arrows.