RMSD and RMSF profile for WT-ANG and mutants.

<p>(A) Control plots representing the stability of the models during the molecular dynamics run. The root mean square deviation (RMSD) of the backbone atoms from the equilibrated conformation (0 ns) is presented as a function of time. The RMSD time profiles for WT-ANG, K17I, S28N, P112L, L35P, K60E and V113I are shown in black, red, dark green, blue, orange, pink, and light green, respectively. (B) Root mean square fluctuation (RMSF) values of atomic positions computed for the backbone atoms are shown as a function of residue number. The RMSF values for WT-ANG, K17I, S28N, P112L, L35P, K60E and V113I are shown in black, red, dark green, blue, orange, pink, and light green, respectively.