Mitochondria in APP and APP/PS1 mouse brains acquire abnormal shape.

<p><b>A.</b> 2D EM micrograph of mitochondrion with abnormal shape in Hip tissue of APP mouse 40 weeks of age. <b>B.</b> 3D reconstruction of ten serial sections of consecutive EM micrographs of the same tissue as in (<b>A</b>). <b>C.</b> 3D reconstruction of mitochondrial structure in Hip tissue of APP/PS1 mouse 24 weeks of age. Note the dramatic elongation of mitochondrion in APP/PS1 tissue compared to the length and shape of the organelle in the brain of NTG mouse of the same age (<b>D</b>). Scale bar, 1 µm.