Motor neuron mitochondria are rounder in mutant SOD1 mice.

<p>MitoEGFP (<i>green</i>) expression in spinal cord motor neurons in control MitoEGFP (A) and SOD1^G37R early symptomatic animals (B–D). The control neuron has normal mitochondria of diverse shapes and sizes. In contrast, SOD1^G37R motor neurons have rounded swollen mitochondria with uneven distribution. Arrows indicate possible axon hillocks. Motor neuron boundaries have been outlined with dotted line. Quantification of mitochondrial length (E) and aspect ratio (F) in motor neuron cell bodies of mutant SOD1 animals of various ages and age-matched MitoEGFP control animals. ***, p<0.0005. Scale bars, 10 µm.