IL-12 and IFN-γ are required to survive tularemia.

<p>IL-12p40^−/− (n = 10), IL-12p35^−/− (n = 10), IFN-γR^−/− (n = 10) and C57Bl/6 (n = 5/experiment) (wild type, WT) mice were intranasally infected with 50 CFU/25 µl SchuS4. Beginning on day 3 after infection, mice were treated once daily with 5 mg/kg LVF diluted in 5% dextrose water for 14 days. * = p<0.05 compared to untreated mice and LVF treated IL-12p40^−/−, IL-12p35^−/−, IFN-γR^−/− animals. ** = p<0.05 compared to all other groups of mice. Data in each graph is representative of 2 experiments of similar design.