Innate antibody response is dispensable for protection during acute phase of tularemia.

<p>(A-B) Levels of IL-1β and IL-18 measured in serum (mean ± SD of two independent experiments, n = 6 mice, Student’s t-test, *p<0.05 or **p<0.01 indicates the difference from wildtype mice at 6 dpi). (C) Level of anti-Ft LPS IgM antibody titer measured in serum (mean ± SD of OD₄₅₀ from two independent experiments, n = 6 mice, Student’s t-test). (D) Levels of anti-Ft IgG and IgA antibodies measured in serum (mean ± SD of OD₄₅₀ from two independent experiments, n = 6, Student’s t-test).