MSX-122 blocks metastasis in an experimental animal model of breast cancer metastasis.
- Zhongxing Liang (173875)
- Weiqiang Zhan (173880)
- Aizhi Zhu (173883)
- Younghyoun Yoon (173887)
- Songbai Lin (173891)
- Maiko Sasaki (173893)
- Jan-Michael A. Klapproth (173899)
- Hua Yang (120668)
- Hans E. Grossniklaus (167806)
- Jianguo Xu (12151)
- Mauricio Rojas (173910)
- Ronald J. Voll (173916)
- Mark M. Goodman (173923)
- Richard F. Arrendale (173928)
- Jin Liu (12833)
- C. Chris Yun (173933)
- James P. Snyder (173937)
- Dennis C. Liotta (94118)
- Hyunsuk Shim (173944)
Publication date
April 2012
DOIAbstract
<p>(A) Representative photographs of 5 lungs were shown from each group. (B) Histological quantization shows a decrease in tumor area in the treated group. Quantitative real-time RT-PCR of human CXCR4 confirms that animals injected with MDA-MB-231 cells and treated with vehicle develop lung metastasis. On the other hand, animals injected with MDA-MB-231 cells and treated with MSX-122 (4 mg/kg, i.p., daily) develop significantly less metastasis.</p
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