MSX-122 blocks metastasis in two more animal models for metastasis.

<p>(A) Non-invasive [¹⁸F]FDG-PET imaging of lung metastasis in head and neck cancer animal models. Three randomly selected mice revealed lung metastases in all mice in the control group; significantly less metastasis was found in the MSX-122 (10 mg/kg i.p., daily) treated group. Left panels show the axial images of three subjects from the control group (bottom) and three from the treated group (top). Right panels show the corresponding coronal images of the same mice. White arrows indicate metastasized SCCHN tumor cells. (B) The inhibition effect of MSX-122 (10 mg/kg i.p., daily) in a uveal melanoma micrometastasis animal model. Micrometastatic clones in liver are shown by small white arrows in the images. MSX-122 significantly decreased the numbers of hepatic micrometastases.