AR strength could be reduced by the bath application of a low concentration of TTX.

<p>(A) Example recording from epileptic rat tissue showing the occurrence of FS autaptic and FS-PC synaptic AR before the application of TTX. Parts of the traces were expanded for clarity. (B) During the period from 120 to 180 s following the onset of 100 nM TTX application, the autaptic and synaptic AR were substantially reduced. Note that the synchronous release during the train stimulation was largely preserved. Same cell as in (A). (C) Group data from FS neurons with autaptic connections showing that both the PT-AR duration and total number of events were significantly reduced in the presence of TTX (100 nM). (D) In FS-PC pairs, TTX had no significant effects on the synaptic strength (the average peak amplitude of the first IPSC), the success rate, and the integrated charge of IPSCs evoked during the train stimulation, but significantly reduced the PT-AR duration and total number of events. * <i>p</i><0.05; ** <i>p</i><0.01.