Aβ depresses synaptic transmission.

<p>(A) Changes in normalized EPSC amplitudes plotted against time in presence of Aβ oligomers, vehicle, scrambled and monomeric Aβ. Neurons were patched and held at −60 mV and responses were evoked throughout the experiment. After baseline recording, Aβ (red trace), vehicle (blue trace), scrambled Aβ (sAβ, green trace) or monomeric Aβ (mAβ, yellow trace) were applied to the bath solution. The arrow indicates when either the peptides or the vehicle solution was bath applied. Averaged traces taken during baseline recording and 15 min after peptide or vehicle application (horizontal black bars in the scatter blot) are shown above the graph. Scale bars: horizontal 0.1 s; vertical 10 pA. (B) Quantification of the experiment shown in A. Acute Aβ perfusion leads to a fast induction of synaptic depression. (*p<0.01, n = 6).