Neurotrasmitter release is affected by Aβ.

<p>(<b>a</b>) Induction of CA1- LTP after HFS in control hippocampal slices (Two-way ANOVA p = 0.0006 n = 5). (<b>b</b>) Induction of CA1-LTP after HFS is blocked in hippocampal slices after a 45 min bath application of Aβ42. (<b>c</b>) fEPSPs recorded in the CA1 in response to a 50 V stimulus of the Schaffer collateral commissural pathway showed a concentration dependent effect of Aβ in fEPSPs. Only mid-range concentrations of 0.3 nM and 1 nM were able to increase the fEPSP slope (p = 0.028 and p = 0.048 respectively with student t-test, n = 5 for each concentration tested). (<b>d</b>) Treatment with Aβ42 (45 min) increases the stimulation response compared to control, untreated slices over a range of stimuli. Results are presented as the percentage of the maximum fEPSP from control recordings (n≥5 each). Inlet in shows a trace of EPSP slopes between a control slice and a slice treated with Aβ42 stimulated at 50 V. (<b>e</b>) Chelation of Aβ42 using 6E10, a specific antibody for the peptide, abrogates the enhancement at all input values (n = 5). (<b>f</b>) Scrambled Aβ did not induce increased responses compared to controls.