Figure 2

<p>(a) As for <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002509#pcbi-1002509-g001" target="_blank">Fig. 1c</a>, but with only main-chain atoms (N, O, C, C, H) included in the force calculation. (b) Mean inter-residue forces (main-chain only) for beta strands 1 and 5. (c) & (d) Distributions of main-chain–main-chain force vs C separation for the residue pairs Gln2-Glu64 (c) and Ile3-Ser65 (c). Each dot corresponds to a single frame from the MD trajectory. The vertical red line shows the mean separation, and the blue curve is a local polynomial fit to the data using the Loess method. The inset highlights the relevant residue pair in the beta sheet structure.