Phylogenetic analysis of the five EBV genomes.

<p>Phylogenetic tree based on DNA and protein sequences of the five EBV strains. (A) DNA sequence of complete genome of the five strains, with poorly aligned and highly divergent sequences masked by Gblocks. Phylogenetic trees based on protein sequence alignment of (B) BZLF1, (C) LMP1, and (D) EBNA1 were generated. All these trees showed a closer distance among the three NPC-related EBV strains, GD1, GD2, and HKNPC1, than the other two viral strains. Phylogenetic analysis was performed using MEGA software (version 5), by Neighbor-joining (NJ) algorithm. Divergence scale, in numbers of substitution per site, is shown under each tree.