<p><b>does not result in increased expression of </b><b><i>lin-28::gfp::lin-28</i></b><b>.</b> (A, B) Representative fluorescent micrographs of <i>lin-28::gfp::lin-28</i> transgene expression at in (A) <i>mir-48/84/241</i> and (B) <i>mir-52; mir-48/84/241</i> worms in the L2 molt stage with corresponding DIC images, (C and D, respectively). Strains were scored for expression of <i>lin-28::gfp::lin-28</i> at the L2 molt (n = 17). No significant difference was observed between strains (χ<sup>2</sup>, p>0.05).</p
<p>(A) L4 stage wild type, <i>mir-35-41(gk262)</i> and <i>mir-35-41(gk262)</i>; <i>apEx160 [mir-35-4...
<p>(A) In wild-type animals, transcriptional activation of miRNAs and <i>lin-42</i>-regulated mRNAs ...
<p>Lineage patterns characteristic of lateral hypodermal seam cells V1, V2, V3, V4 and V6. Left to r...
<p>, <b>function in multiple miRNA-dependent developmental pathways.</b> (A, B) <i>mir-52</i> suppre...
<p>(A–E) Effect of <i>mir-52</i> on <i>lsy-6</i> mediated regulation of <i>cog-1::gfp::cog-1</i> exp...
<p>(A) Northern blot analyses of <i>lin-35/Rb</i> mRNA levels in WT, <i>mir-35-41(gk262)</i> and <i>...
<p>(A) Small RNA northern analysis of 20 µg of total RNA extracted from morphologically staged, youn...
<p>(A) The <i>pmk</i> operon translational reporter. Green fluorescent protein was engineered onto t...
a<p>Full genotype information can be found in <a href="http://www.plosone.org/article/info:doi/10.13...
a<p>full genotype information can be found in <a href="http://www.plosone.org/article/info:doi/10.13...
<p>Levels of mature miRNAs in wild type, <i>mir-52</i>, and <i>mir-52/53/54/55/56</i> mutant worms w...
<p>(A) The genomic locus of <i>lin-42</i> and the corresponding location of the mutations identified...
<p><b>(A) Quantification of microRNA expression</b>. The levels of miR-48 and miR-241 were measured ...
<p><b>A</b>) Analysis of the <i>let-60</i>-mediated Muv phenotype. Left panels: Nomarski pictures of...
a<p>Animals contain <i>maIs105</i>, an adult-specific <i>col-19pro::GFP</i> reporter that is integra...
<p>(A) L4 stage wild type, <i>mir-35-41(gk262)</i> and <i>mir-35-41(gk262)</i>; <i>apEx160 [mir-35-4...
<p>(A) In wild-type animals, transcriptional activation of miRNAs and <i>lin-42</i>-regulated mRNAs ...
<p>Lineage patterns characteristic of lateral hypodermal seam cells V1, V2, V3, V4 and V6. Left to r...
<p>, <b>function in multiple miRNA-dependent developmental pathways.</b> (A, B) <i>mir-52</i> suppre...
<p>(A–E) Effect of <i>mir-52</i> on <i>lsy-6</i> mediated regulation of <i>cog-1::gfp::cog-1</i> exp...
<p>(A) Northern blot analyses of <i>lin-35/Rb</i> mRNA levels in WT, <i>mir-35-41(gk262)</i> and <i>...
<p>(A) Small RNA northern analysis of 20 µg of total RNA extracted from morphologically staged, youn...
<p>(A) The <i>pmk</i> operon translational reporter. Green fluorescent protein was engineered onto t...
a<p>Full genotype information can be found in <a href="http://www.plosone.org/article/info:doi/10.13...
a<p>full genotype information can be found in <a href="http://www.plosone.org/article/info:doi/10.13...
<p>Levels of mature miRNAs in wild type, <i>mir-52</i>, and <i>mir-52/53/54/55/56</i> mutant worms w...
<p>(A) The genomic locus of <i>lin-42</i> and the corresponding location of the mutations identified...
<p><b>(A) Quantification of microRNA expression</b>. The levels of miR-48 and miR-241 were measured ...
<p><b>A</b>) Analysis of the <i>let-60</i>-mediated Muv phenotype. Left panels: Nomarski pictures of...
a<p>Animals contain <i>maIs105</i>, an adult-specific <i>col-19pro::GFP</i> reporter that is integra...
<p>(A) L4 stage wild type, <i>mir-35-41(gk262)</i> and <i>mir-35-41(gk262)</i>; <i>apEx160 [mir-35-4...
<p>(A) In wild-type animals, transcriptional activation of miRNAs and <i>lin-42</i>-regulated mRNAs ...
<p>Lineage patterns characteristic of lateral hypodermal seam cells V1, V2, V3, V4 and V6. Left to r...