Location of genetic markers in chromosomal region (11q23.3) (195 Kb) encompassing <i>BUD13-ZNF259, APOA5-A4-C3-A1,</i> and <i>SIK3</i> gene cluster.

<p>Exons are shown in black vertical rectangles separated by introns. Significant SNPs (associated with increased triglyceride concentrations) detected in <i>BUD13</i>, <i>ZNF259</i> and <i>SIK3</i> are shown in large rectangles on disequilibrium (LD) matrix with their position on the genes indicated by lines. The direction of transcription of genes is shown in arrows. Pair-wise LD between SNPs (D’) is indicated by diamonds shaded in white-grey-black show the range of LD matrix from D’ = 0 in white to D’ = 1 in black. LD block 1 contains 5 most significant SNPs including two top SNPs (rs964184 and rs7350481) of the total 45 analyzed. LD block 2 shows all SNPs from <i>the SIK3</i> gene and the presence of a strong LD among these SNPs containing two strong signals associated with triglycerides in rs10047459 and rs533556.