Levels of Myc affect mitochondrial structure in rat fibroblasts.

<p>(<b>a</b>) <i>Mitochondrial ultrastructure</i>. The indicated cell lines were examined by transmission electron microscopy. Representative mitochondria are presented. Note the smaller and cristae-deficient mitochondrion of the <i>myc−/−</i> cells (arrow) and the complete restoration of this defect in <i>myc−/−</i>wtMyc cells. (<b>b</b>) <i>Mitochondrial length</i>. Mean mitochondrial length in each cell line was determined by measuring at least 30 individual mitochondria from images of multiple cells obtained by transmission electron microscopy. The student t-test was used to calculate the p-values indicated in the figure.