Electron photomicrographs showing mitochondria localization in rat peritoneal mast cells and human mtDNA presence in rat serum.

<p>Male rat peritoneal mast cells (A) control with intact electron dense granules and mitochondria inside the cell. (B, C) after C48/80 stimulation showing (B) intense degranulation (*) with most mitochondria at the cell surface close to sites of exocytosis (Magnification: 13,800×), and (C) extracellular mitochondria outside the cell perimeter (Magnification: 4,500×). Mitochondria is shown within red rectangles. (D) Presence of human mitochondria in rat serum following ip injection in male rats (n = 4).