Gene Ontology and KEGG pathway analyses

<p>(<b>reference = all genes</b>)<b>.</b> Gene Ontology Biological Process (GO_BP) and KEGG pathway analyses for probes with greater variance in childhood than in adulthood using as reference all genes called present on the array. The <i>expected</i> number of genes is the number of genes predicted for this term by random chance. The <i>observed</i> number of genes is the number of genes actually present in our dataset for this term. For example, in this context we would expect by random chance to see 13 genes annotated to the GO_BP term ‘immune system process’ (GO:0002376). Instead, we observed 75 genes annotated to this term (pFDR = 0). The steepness of the slope of each line reflects statistical significance with steeper lines having smaller pFDR values. Those categories with the greatest slope (pFDR = ≤0.02) are labeled in this figure. All 339 GO_BP terms and 19 KEGG pathways that met our enrichment criterion of pFDR ≤0.1 can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037714#pone.0037714.s005" target="_blank">Dataset S2</a>. Additional GO (Molecular Process and Cellular Component) data and plots can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037714#pone.0037714.s005" target="_blank">Dataset S2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037714#pone.0037714.s001" target="_blank">Figure S1</a> respectively.