<p>Peptides that interacted with p53NRD (p53 361–393) are marked in green. The peptide WS100B(81–92) that interacted with p53Tet is marked in yellow. The peptide PKCα(281–295) that bound more tightly to full-length p53CTD than to p53NRD is marked in red.</p
The complex between the proteins MDM2 and p53 is a promising drug target for cancer therapy. The res...
Screening of arrays and libraries of compounds is well-established as a high-throughput method for d...
Screening of arrays and libraries of compounds is well-established as a high-throughput method for d...
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating th...
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating th...
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating th...
<p>Biotinylated CTD peptides bearing four heptad repeats (28-mers) that were unphosphorylated (CTD),...
<p>p53CTD was titrated into a solution of fluorescein-labeled peptide and the changes in anisotropy ...
<p>(A) ASPP2 Ank-SH3 binds ASPP2 Pro 722–737 with <i>K</i><sub>d</sub> = 0.68±0.07 µM. (B) p53CD was...
<p>F2H assay to investigate the interaction of p53 (bait) with wild-type HDM2 (WT), mutant Q24R and ...
S100B(ββ) is a member of the S100B protein family and is distributed in a cell-specific manner. Its...
<p>A, Models of the native (left) and V280A mutant (right) peptides docked to the p53 DNA binding do...
Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targete...
Background:The peptide segment surrounding residues Leu22 and Trp23 of the p53 transactivation domai...
<p>(a) MD derived interactions. tBRCT is shown in surface representation in light gray and the p53 C...
The complex between the proteins MDM2 and p53 is a promising drug target for cancer therapy. The res...
Screening of arrays and libraries of compounds is well-established as a high-throughput method for d...
Screening of arrays and libraries of compounds is well-established as a high-throughput method for d...
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating th...
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating th...
Oligomerization plays a major role in regulating the activity of many proteins, and in modulating th...
<p>Biotinylated CTD peptides bearing four heptad repeats (28-mers) that were unphosphorylated (CTD),...
<p>p53CTD was titrated into a solution of fluorescein-labeled peptide and the changes in anisotropy ...
<p>(A) ASPP2 Ank-SH3 binds ASPP2 Pro 722–737 with <i>K</i><sub>d</sub> = 0.68±0.07 µM. (B) p53CD was...
<p>F2H assay to investigate the interaction of p53 (bait) with wild-type HDM2 (WT), mutant Q24R and ...
S100B(ββ) is a member of the S100B protein family and is distributed in a cell-specific manner. Its...
<p>A, Models of the native (left) and V280A mutant (right) peptides docked to the p53 DNA binding do...
Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targete...
Background:The peptide segment surrounding residues Leu22 and Trp23 of the p53 transactivation domai...
<p>(a) MD derived interactions. tBRCT is shown in surface representation in light gray and the p53 C...
The complex between the proteins MDM2 and p53 is a promising drug target for cancer therapy. The res...
Screening of arrays and libraries of compounds is well-established as a high-throughput method for d...
Screening of arrays and libraries of compounds is well-established as a high-throughput method for d...