<p>(A) ASPP2 Ank-SH3 binds ASPP2 Pro 722–737 with <i>K</i><sub>d</sub> = 0.68±0.07 µM. (B) p53CD was titrated into the fully formed complex between ASPP2 Ank-SH3 and Fl-ASPP2 722–737 and displaced the Fl-ASPP2 722–737 peptide.</p
(A) Domain organizations of p53 and ASPP proteins. p53’s DBD and ASPP’s ANK-SH3 are folded domains w...
Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with...
Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with...
<p>(A) A peptide derived from the proline rich domain of ASPP2 residues 722–737 binds the ASPP2 n-sr...
<p>(A) ASPP2 Ank-SH3 binds Fl-ASPP2 722–737 with K<i><sub>d</sub></i> = 0.82±0.08 µM (magenta); (B) ...
<p>(A) p53CD binds Fl-ASPP2 1089–1097 ASPP2 SH3 derived peptide In fluorescence anisotropy experimen...
<p>(A) ASPP2 Ank-SH3 binds Fl-NFκB 303–332 with K<i><sub>d</sub></i> = 0.13±0.01 µM; (B) Non-labeled...
ASPP2 is a key protein in regulating apoptosis both in p53-dependent and-independent pathways. The C...
ASPP2 is a key protein in regulating apoptosis both in p53-dependent and-independent pathways. The C...
ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. The C terminus...
ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. The C terminus...
<p>(A) Crystal structure of the complex between p53CD (black) and ASPP2 927–1119 (gray). The RT loop...
SummaryASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p...
ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Bin...
ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Bin...
(A) Domain organizations of p53 and ASPP proteins. p53’s DBD and ASPP’s ANK-SH3 are folded domains w...
Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with...
Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with...
<p>(A) A peptide derived from the proline rich domain of ASPP2 residues 722–737 binds the ASPP2 n-sr...
<p>(A) ASPP2 Ank-SH3 binds Fl-ASPP2 722–737 with K<i><sub>d</sub></i> = 0.82±0.08 µM (magenta); (B) ...
<p>(A) p53CD binds Fl-ASPP2 1089–1097 ASPP2 SH3 derived peptide In fluorescence anisotropy experimen...
<p>(A) ASPP2 Ank-SH3 binds Fl-NFκB 303–332 with K<i><sub>d</sub></i> = 0.13±0.01 µM; (B) Non-labeled...
ASPP2 is a key protein in regulating apoptosis both in p53-dependent and-independent pathways. The C...
ASPP2 is a key protein in regulating apoptosis both in p53-dependent and-independent pathways. The C...
ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. The C terminus...
ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. The C terminus...
<p>(A) Crystal structure of the complex between p53CD (black) and ASPP2 927–1119 (gray). The RT loop...
SummaryASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p...
ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Bin...
ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Bin...
(A) Domain organizations of p53 and ASPP proteins. p53’s DBD and ASPP’s ANK-SH3 are folded domains w...
Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with...
Tumor suppressors p53, p63 and p73 comprise a family of stress-responsive transcription factors with...
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