Rosuvastatin induced actin-cytoskeleton reorganization, cell adhesion and migration in agLDL-VSMC is dependent on the RhoA/ROCK signaling pathway.

<p>agLDL-VSMC incubated with rosuvastatin in absence/presence of inhibitors for ROCK (Y27632) or MLCK (ML9) were analyzed for (<b>A</b>) filamentous actin organization during cell attachment. Note that rosuvastatin-promoted filamentous actin organization in LDL-VSMC was prevented by Y27632 (<b>B</b>) cell attachment (expressed as percentage of the control group) (*) <i>vs</i> agLDL and (#) <i>vs</i> agLDL+ rosuvastatin group, p<0.01 (Mann Whitney test). (<b>C</b>) wound repairing (*) <i>vs</i> agLDL p<0.01 (Mann Whitney test) and (#) <i>vs</i> agLDL+ rosuvastatin group, p<0.01 (Mann Whitney test). In B and C, bar diagrams represent the mean±SEM of 3 independent experiments.