Density of transcription and splicing regulation inedges.

<p>(A) Distribution of transcription regulation inedges for the three subgroups of network targets: SFs (red), TFs (blue) and kinases (yellow) (network reconstructed based on Dataset A). (B) Distribution of splicing regulation inedges for the three subgroups: SFs (red), TFs (blue) and kinases (yellow). (C) A diagram summarizing the transcription and AS predicted interactions among the three subgroups in the network; the arrows represent interactions across and between subgroups (blue and red arrows for transcriptional and splicing regulation, respectively). The average density of inedges per group is shown in numbers within the arrow and is represented by the color intensity of the arrow. As demonstrated, cross-regulation is far more prevalent than cross-talk for both transcriptional and AS regulation.