Schematic representation of the integrated network construction.

<p>(A) Three representative examples of different types of regulatory interactions in the integrated network. On the left are illustrations of the network interactions: red and blue arrows represent splicing and transcription regulation, respectively, accordingly large red and blue circles represent SF and TF nodes, respectively. On the right are sketches illustrating how each interaction was defined: small red and blue circles represent predicted splicing or transcription binding motifs, respectively. The color of the transcript illustrated is as follows: red for genes belonging to the SF group, blue for genes belonging to the TF group and yellow for genes belonging to the kinase group. The top row demonstrates the splicing regulatory interaction between two SFs, the middle row demonstrates the transcription regulatory interaction between two TFs, and the bottom row represents splicing and transcription interactions of a node belonging to the kinase group. (B) Illustration of the network architecture: the top row represents the source layer, including two types of nodes (SF, TF) with only outedges of splicing and transcription (source), the middle row includes two types of nodes (SF, TF) having both inedges and outedges (mixed layer), and the bottom row includes three types of nodes (SF, TF and kinases) having only inedges (sink).