Loss of CHD1 renders flies more susceptible to oral but not to systemic infection by <i>P. aeruginosa</i>.

<p>(A) Kaplan-Meier plots displaying survival rates of female <i>Chd1^−/−</i>, <i>Chd1^WT/WT</i>, <i>Tl^rv1/Tl^r3</i> and <i>Dredd^EP1412</i> flies after feeding with 5% sucrose solution containing either <i>S. aureus</i>, <i>P. aeruginosa</i> (both 10⁹–10¹⁰ cfu/ml), <i>R. oryzae</i> (5×10⁸ spores/ml) or no microbes for 15 h. <i>Chd1-</i>deficient flies are significantly more susceptible to oral infections with <i>S. aureus</i> and <i>P. aeruginosa</i> (*P<0.05; n = 80) than <i>Chd1^WT/WT</i> flies. (B) Survival rates of female <i>Chd1^−/−</i>, <i>Chd1^WT/WT</i>, <i>Tl^rv1/Tl^r3</i> and <i>Dredd^EP1412</i> flies following septic injury with different microbe solutions or NaCl as above (10⁶–10⁷ cfu or spores/ml). No significant differences of survival of infected <i>Chd1^−/−</i> (n = 200) and <i>Chd1^WT/WT</i> (n = 320) flies were observed.