The stability of miRNA species expression in hematopoietic samples.

<p>The stability of miRNA species expression using 41 samples of leukaemic and non-leukaemic cell lines, paediatric archived bone marrow aspirate slides (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042951#pone.0042951.s002" target="_blank">Table S1</a>), and 14 potential miRNA candidates (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042951#pone.0042951.s003" target="_blank">Table S2</a>). geNorm and NormFinder (NF) were used to calculate the expression stability values for each miRNA tested. The most ‘stably’ expressed gene in a sample group is that with an average expression stability value (<i>M</i>) closest to zero. The most stably expressed miRNA were; NF Ungrouped: hsa-miR-16 <i>M</i> = 1.143; NF Grouped by Cancer Status: hsa-miR-16 <i>M</i> = 0.457; NF Grouped by Leukaemia subtype: hsa-miR-16 <i>M</i> = 0.573; geNorm: hsa-miR-16 and hsa-miR-26b are equal at <i>M</i> = 1.817.