<p>(<b>A</b>) Cytokine producer frequency (%, gating on viable CD3<sup>+</sup> T cells) at baseline and different time points thereafter. The numbers on the x-axis (1, 2, 3, 4, 5 and 6) are the patient ID. Abbreviations: BL = Base Line; PI-2 = Prior to 2<sup>nd</sup> Infusion; PI-3 = Prior to 3<sup>rd</sup> Infusion, W = Week post final infusion. (<b>B</b>) The normalised MFI, corresponding to the responses detected in (A). (<b>C</b>) T cell quality in PT#4 and PT#5, depicted by the normalised MFI of cytokine positive responses. (<b>D</b>) The frequency (%) and normalised MFI over time in PT#3. (<b>E</b>) The dose and timing of DC infusion each patient received and the timing of sample collection. (<b>F</b>) Contribution of CD4 and CD8 T ce...
<p>(A) A representative plot of CD4<sup>+</sup> T cells expressing PD-1 upon CW stimulation, display...
<p>Samples were stimulated with PMA-Ionomycin for 3 hours. Rows represent different maturational cel...
<p>(A) the graph shows the frequency of responding donors to all cytokines (eg one positive hit for ...
<p>(A) Magnitude of T cell cytokine responses to JEV SA14-14-2 detected by flow cytometry/ICS in fiv...
<p>(A) CD4+ response rates. (B) CD4+ response magnitude. (C) CD8+ response rate. (D) CD8+ response m...
<p>Cytokine concentrations in plasma at M0 have been plotted against CD4<sup>+</sup> T cell counts a...
<p>Flow cytometry evaluation of CD4<sup>+</sup> T-cell response to AgB. <b>A.</b> Magnitude of the c...
<p><b>A)</b> Live single cell CD14- CD19- events were gated on CD3, followed by gating for CD4 and t...
<p>Mean percent and standard error of the mean (SEM) of CD4+ and CD8+ PBMCs producing antigen-specif...
<p>(<b>A</b>) The relative frequencies of the PPD-specific CD4+CD45RO+ T-cell subsets in QFT consist...
<p>Initial (left) data point in each series represents control unstimulated (basal) condition, while...
<p>(<b>A</b>) Lymphocytes were gated based on FSC and SSC, followed by a CD3<sup>+</sup>ViViD<sup>−<...
<p>(A) The magnitude of antigen-specific CD4 T cells expressing any of the 3 cytokines measured (i.e...
<p>Intracellular cytokine/chemokine production is shown as the percentage of positive cells. Respons...
<p>A. Geometric mean CS-specific CD4<sup>+</sup> T cells producing IFN-γ by ELISpot. Comparisons bet...
<p>(A) A representative plot of CD4<sup>+</sup> T cells expressing PD-1 upon CW stimulation, display...
<p>Samples were stimulated with PMA-Ionomycin for 3 hours. Rows represent different maturational cel...
<p>(A) the graph shows the frequency of responding donors to all cytokines (eg one positive hit for ...
<p>(A) Magnitude of T cell cytokine responses to JEV SA14-14-2 detected by flow cytometry/ICS in fiv...
<p>(A) CD4+ response rates. (B) CD4+ response magnitude. (C) CD8+ response rate. (D) CD8+ response m...
<p>Cytokine concentrations in plasma at M0 have been plotted against CD4<sup>+</sup> T cell counts a...
<p>Flow cytometry evaluation of CD4<sup>+</sup> T-cell response to AgB. <b>A.</b> Magnitude of the c...
<p><b>A)</b> Live single cell CD14- CD19- events were gated on CD3, followed by gating for CD4 and t...
<p>Mean percent and standard error of the mean (SEM) of CD4+ and CD8+ PBMCs producing antigen-specif...
<p>(<b>A</b>) The relative frequencies of the PPD-specific CD4+CD45RO+ T-cell subsets in QFT consist...
<p>Initial (left) data point in each series represents control unstimulated (basal) condition, while...
<p>(<b>A</b>) Lymphocytes were gated based on FSC and SSC, followed by a CD3<sup>+</sup>ViViD<sup>−<...
<p>(A) The magnitude of antigen-specific CD4 T cells expressing any of the 3 cytokines measured (i.e...
<p>Intracellular cytokine/chemokine production is shown as the percentage of positive cells. Respons...
<p>A. Geometric mean CS-specific CD4<sup>+</sup> T cells producing IFN-γ by ELISpot. Comparisons bet...
<p>(A) A representative plot of CD4<sup>+</sup> T cells expressing PD-1 upon CW stimulation, display...
<p>Samples were stimulated with PMA-Ionomycin for 3 hours. Rows represent different maturational cel...
<p>(A) the graph shows the frequency of responding donors to all cytokines (eg one positive hit for ...