Necropsy gross anatomical findings.

<p>A. Whole liver from terminally infected animal. Note the marked congestion and extensive pan-lobular zone of hepatic damage due to infarction near the liver hilus that is surrounded by a well-demarcated hyperemic rim of hepatic parenchyma (arrow). B. Cross-section of the liver in panel A at the level of the main portal vein through the center of a zone of hepatic necrosis and infarction (asterisk). C. Another example of the severe hepatic congestion, necrosis, and infarction observed in all terminal cases (arrow). D. Frank hemorrhage (>35 mL) in the abdominal cavity. E. Severely congested and hemorrhagic mesenteric lymph nodes (asterisks), and severe congestion and hemorrhage on the serosal surface of the cecum (arrows). F. Mucosal surface of the cecum in panel E; note the severe congestion and extensive petechiation. G. Example of the severe dilated cardiomyopathy observed in the majority of infected animals beginning at approximately day 12 PI. H. Serosal surface of the bladder; note the severe petechiation. I. Contents of the bladder in panel H, consistent with hematuria and frank hemorrhage collected <i>in situ</i> by cystocentesis. Panels A, B, C, G, H (wtLUJV infected). Panels D, E, F (recLUJV infected).