Patho-Histologic studies on the Disses Space of the Liver in Epidemic Hepatitis part Ⅰ Comparison Between the Biopsy-Findings and the Autopsy-Findings of the Liver

Since Iversen, P. and Rohom, K. attempted the liver-biopsy and reported that it was a valuable method to make the diagnosis of liver-diseases in 1939, the liver-biopsy has been used for making the diagnosis of liverdiseases. But one scholar described that the patho-histologic findings of the liver on liver-biopsy are not just same with those on autopsy. For the purpose to find the degree of the above differences, I made the acute and subacute liver damages in dogs with the subcutaneous infection of Allyl formate, and studied the biopsy-findings and autopsy-findings of the liver. And I found the following resultes: 1. The biopsy-findings of the acute and subacute diffuse changes in the whole liver agree with the histological findings of the autopsymaterials at the early stage of death. It is thought, especially, Disses space is not the artificial product from the liver-biopsy and the pathologic studies on it are necessary. 2. The tissues from the liver-biopsy are so small that the observation of the Disses apace and the determination of the blood volume in it are occasionally difficult. But it can be supplied the deficiency of the biopsy to use the methodes for silver impregnation and other stains and the completion of the continual pieces