KEGG Pathway co-membership and co-differential expression gene set networks.

<p>In the KEGG Pathway gene set networks nodes represent KEGG Pathways; green nodes are metabolic pathways and purple nodes are non-metabolic pathways. A) The KEGG Pathway co-membership gene set network represents pathway crosstalk with an edge indicating a significant degree of crosstalk. B) The KEGG Pathway co-differential expression (co-DE) gene set network is constructed using the co-enrichment method applied to over five thousand differentially expressed gene lists derived from gene expression microarray data. C) A novel “Folding, Sorting, and Degradation” module is unique to the co-DE gene set network.