Co-administration of pC191 and pAAV/HBV1.3 by HI reduced HBV replication and gene expression in vivo.

<p>BALB/c (H-2^d) mice (n = 12 for each group) were subjected to HI with different plasmids combinations. Sera were collected and subjected to HBsAg and HBV DNA detection at the indicated time points. The kinetics of HBsAb total IgG and IgG subclasse responses after HI in BALB/c (H-2^d) mice were tested by ELISA assay. (A) Positive rate of serum HBsAg in the mice from each group. (B) The kinetics of the HBsAg titer after HI. (C) The kinetics of HBV DNA detection in the mice. The kinetics of the total HBsAb IgG (D), IgG1 (E) and IgG2a (F) titres after HI. The results shown represent the average of all of the mice. The error bars represent the standard deviations. Statistically significant differences between the groups are displayed as *(p<0.05) and **(p<0.01).