Frequency and relative effect size of haplotype between rs11878604 (SNP) and rs8102683 (CNP).

¶<p>Haplotypes consisting of alleles at rs11878604 [T/C] and haplotypic copy numbers at rs8102683 [0/1/2].</p>*<p>Haplotype frequencies and relative effect sizes are jointly evaluated using a haplotype-specific linear regression model as described previously <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044507#pone.0044507-Stram1" target="_blank">[27]</a>. All model parameters were estimated using a standard EM (expectation-maximization) algorithm <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044507#pone.0044507-McLachlan1" target="_blank">[28]</a>.</p>†<p>Variance explained by these six haplotypes and its significance was assessed in the standard ANOVA (analysis of variance) framework.