<p>Shown are the models described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088425#pone-0088425-g002" target="_blank">Fig. 2</a> left (L), middle (M) and right (R) considering various levels of population size reductions to N<sub>ei</sub> = 100, 500, 3,000 and 7,000. The grey dashed line indicates the probability of 5% of the most common haplotype to reach a frequency ∼0.72 or higher.</p
<p>Here is the dominance parameter, as described in the section entitled Fitness Calculation. The s...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
<p>Odds ratios for each haplotype in the best-fitting model for each JIA subtypes, with 95% CI (grey...
¶<p>Haplotypes consisting of alleles at rs11878604 [T/C] and haplotypic copy numbers at rs8102683 [0...
<p>(A) We observe a population with different haplotypes. From the population we extract two measure...
<p>Two-loci haplotypes with a frequency higher than 3% (2% for HLA-A); obs: estimated frequency; exp...
<p>For population codes see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.00...
<p>Data was simulated under Scenario 7 (DominantDominant) with and . The table shows the mean of th...
<p>For a similar result derived from analytical modeling, see <a href="http://www.plosgenetics.org/a...
<p>Frequencies and distribution of probable haplotypes in the patient and control groups as predicte...
Motivation: Inference of haplotypes from genotype data is crucial and challenging for many vitally i...
<p>The number of origins of adaptive mutations on unique haplotype backgrounds was measured in simul...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
<p>Note: <i>p</i>, unadjusted <i>p</i> values,* <i>p</i><0.05;</p><p><i>p′</i>, adjusted <i>p</i> va...
<p>Here is the dominance parameter, as described in the section entitled Fitness Calculation. The s...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
<p>Odds ratios for each haplotype in the best-fitting model for each JIA subtypes, with 95% CI (grey...
¶<p>Haplotypes consisting of alleles at rs11878604 [T/C] and haplotypic copy numbers at rs8102683 [0...
<p>(A) We observe a population with different haplotypes. From the population we extract two measure...
<p>Two-loci haplotypes with a frequency higher than 3% (2% for HLA-A); obs: estimated frequency; exp...
<p>For population codes see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.00...
<p>Data was simulated under Scenario 7 (DominantDominant) with and . The table shows the mean of th...
<p>For a similar result derived from analytical modeling, see <a href="http://www.plosgenetics.org/a...
<p>Frequencies and distribution of probable haplotypes in the patient and control groups as predicte...
Motivation: Inference of haplotypes from genotype data is crucial and challenging for many vitally i...
<p>The number of origins of adaptive mutations on unique haplotype backgrounds was measured in simul...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
<p>Note: <i>p</i>, unadjusted <i>p</i> values,* <i>p</i><0.05;</p><p><i>p′</i>, adjusted <i>p</i> va...
<p>Here is the dominance parameter, as described in the section entitled Fitness Calculation. The s...
The logic of gene mapping in highly penetrant diseases is to find the minimal overlap of haplotypes ...
<p>Odds ratios for each haplotype in the best-fitting model for each JIA subtypes, with 95% CI (grey...